The correlation between sleep apnea and structural changes in APOE4 positive Lead Investigator: Toby Eisenberg Institution : Eastern Virginia Medical School E-Mail : eisenbtg@evms.edu Proposal ID : 770 Proposal Description: The goals of this project are to examine the changes in hippocampal volume, mesiotemporal lobe volume and lateral ventricle volume in patients with and without sleep apnea who develop AD while controlling for the APOE gene and variables such as cardiovascular risk factors, education, gender, and depression. We will also examine longitudinal changes in these individuals by analyzing their neuropathology.